The Vega Gang is a Gang working for the cuban Gangster Victor Vega in Gangstar: Miami Vindication. In the game, Johnny meets some Gang members while getting some chaw for Roscoe in Little Havana. He also has to steal a hearse with the body of a cartel boss working for Vega.
During the game, Johnny does a series of jobs against the Vega Gang, e.g. stealing drugs, killing Gang members. The last job against the gang was killing Victor Vega. After doing the job, the gang presumably disbanded.